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It’s time to pay off your dream debt


However, there are many ways to not get enough sleep. You can go without sleep at all for a long period of time: what scientists call acute sleep deprivation (in 1963, a high school student stay awake for 264 hours). You can constantly lose hours of sleep: chronic sleep deprivation. You can be lying down but awake, with your mind racing at full speed or relaxed, watching TV all night. Studies like Manassein’s are considered extreme to the point of being irrelevant to humans.

The research continued, but it was “sort of pigeonholed,” said Fabian Fernandez, a neuroscientist at the University of Arizona who did not contribute to the new review. “When are you going to keep an animal or a human awake until they die?”

However, over the past couple of decades, sleep deprivation research in animals has become more nuanced, precise, and possibly applicable to humans, according to Sigrid Veasey, a neuroscientist at the University of Pennsylvania, and Zachary Zamore, a researcher from the Veasey lab, the authors of the new assessment.

After analyzing past studies of sleep deprivation in mice, many of which were carried out by Veasey, the researchers found that when the animals were allowed to stay awake a couple of hours longer than usual every day, this It particularly affected two key parts of the brain: the locus coeruleus, a nucleus that handles feelings of vigilance and arousal, and the hippocampus, an area that plays an important role in memory formation and learning. These regions, which in humans are essential for maintaining conscious experience, slowed down the production of antioxidants in animals, which protect neurons from unstable molecules that are produced all the time; they are something like the exhaust gases of the cells in operation. When antioxidant levels are low, these molecules can build up and attack the brain from within, breaking down proteins, fats, and DNA.

“Even under normal circumstances, wakefulness in the brain causes damage,” Fernandez said. “But when you’re awake for too long, then the system becomes overloaded. At a certain point, it already becomes impossible. If you ask your cells to stay active 30 percent more every day, the cells die.”

In the brains of mice, sleep deprivation led to cell death within a few days of sleep restriction, a much lower threshold for brain damage than previously thought. Inflammation also occurs in the prefrontal cortex and increases protein levels Tau Y amyloidwhich have been related to neurodegenerative diseases such as Alzheimer’s and Parkinson’s, in the locus coeruleus and the hippocampus.



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